Primary tumour resection in metastatic nonfunctioning pancreatic endocrine carcinomas.

摘要: Abstract Background The role of debulking surgery in metastatic nonfunctioning pancreatic endocrine carcinomas (M-NF-PECs) with resectable primary tumour and unresectable liver metastases is debated. Aim the study to evaluate whether resection carcinoma improves survival. Patients methods Fifty-one patients were enrolled from 1990 2004 at time diagnosis. Nineteen underwent complete whilst 32 judged unresectable. All cases classified according WHO 2000 classification. clinico-pathological parameters, including grade differentiation Ki-67 proliferation index considered univariate multivariate models. Results Of 19 resected patients, 14 (73.7%) left-pancreatectomy 5 (26.3%) pancreaticoduodenectomy. In unresected group 9 (28.1%) surgical biliary and/or gastric by-pass. There was no postoperative mortality median survival 54.3 months (95% CI: 25.7–82.9). No difference observed between two groups [resected: 25–83.6), unresected: 39.5 5.4–73.6); p = 0.74]. Upon analysis poor (HR 3.01; 95% CI 1.08–8.4; p = 0.035) a ≥10% 4.4; 1.2–16.1; p = 0.023) significant predictors Conclusions Resection does not significantly improve can be as symptomatic palliative therapy well-differentiated proliferative lower than 10%.