Effect of anti-cord factor antibody on experimental tuberculosis in mice

摘要: Abstract Either active immunization with trehalose-6, 6′-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor induced in mice an enhanced resistance against infection virulent human Mycobacterium tuberculosis. This suggests that the antibody exerts infection-protecting effect by neutralizing toxic action cord during course living tubercle bacilli. The protective factor-methylated and was found to be specific for tuberculous among a number experimental infections variety cytopathogenic microorganisms tested.