Brain tumor stem cells: The cancer stem cell hypothesis writ large

作者: Peter B. Dirks

DOI: 10.1016/J.MOLONC.2010.08.001

关键词: Neural stem cellStem cellProgenitor cellCancer stem cellNeurosphereClinical uses of mesenchymal stem cellsBiologyPathologyCancer researchStem cell transplantation for articular cartilage repairAdult stem cellMolecular medicineGeneticsGeneral Medicine

摘要: Brain tumors, which are typically very heterogeneous at the cellular level, appear to have a stem cell foundation. Recently, investigations from multiple groups found that human as well experimental mouse brain tumors contain subpopulations of cells functionally behave tumor cells, driving growth and generating progeny form bulk, but then lose tumorigenic ability. In glioblastomas, these express neural precursor markers capable differentiating into more mature lineage markers. addition, modeling in mice suggests readily give rise full blown narrowing potential origin those rarer proliferative potential. Applying concepts methodologies is giving fresh insight biology, mechanisms growth, offering new opportunities for development effective treatments. The field remains young there much be learned before insights translated patient

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