作者: Peter B. Dirks
DOI: 10.1016/J.MOLONC.2010.08.001
关键词: Neural stem cell 、 Stem cell 、 Progenitor cell 、 Cancer stem cell 、 Neurosphere 、 Clinical uses of mesenchymal stem cells 、 Biology 、 Pathology 、 Cancer research 、 Stem cell transplantation for articular cartilage repair 、 Adult stem cell 、 Molecular medicine 、 Genetics 、 General Medicine
摘要: Brain tumors, which are typically very heterogeneous at the cellular level, appear to have a stem cell foundation. Recently, investigations from multiple groups found that human as well experimental mouse brain tumors contain subpopulations of cells functionally behave tumor cells, driving growth and generating progeny form bulk, but then lose tumorigenic ability. In glioblastomas, these express neural precursor markers capable differentiating into more mature lineage markers. addition, modeling in mice suggests readily give rise full blown narrowing potential origin those rarer proliferative potential. Applying concepts methodologies is giving fresh insight biology, mechanisms growth, offering new opportunities for development effective treatments. The field remains young there much be learned before insights translated patient