Protein Complexes in the Nucleus: The Control of Chromosome Segregation
作者： Victor M. Bolanos-Garcia
DOI: 10.1007/978-3-319-46503-6_16
关键词: Spindle checkpoint 、 Cell division 、 Mitosis 、 Biology 、 Condensin 、 Chromosome segregation 、 Spindle apparatus 、 Kinetochore 、 Genetics 、 Cell biology 、 Sister chromatids
摘要: Mistakes in the process of cell division can lead to loss, gain or rearrangement chromosomes. Significant chromosomal abnormalities are usually lethal cells and cause spontaneous miscarriages. However, some cases, defects spindle assembly checkpoint severe diseases, such as cancer birth development defects, including Down’s syndrome. The timely accurate control chromosome segregation mitosis relies on (SAC), an evolutionary conserved, self-regulated signalling system present higher organisms. is orchestrated by dynamic interactions between microtubules kinetochore, a multiprotein complex that constitutes site for attachment chromosomes microtubule polymers pull sister chromatids apart during division. This chapter discusses current molecular understanding essential, highly underpinning how choreography be coordinated time space finely regulate process. potential targeting this pathway interfere with abnormal chromosomes, which occurs diverse malignancies new opportunities recent technological developments opening up deeper also discussed.
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