Oral/intravenous maintenance dosing of valproate following intravenous loading: A simulation

摘要: Valproic acid (VPA) has a narrow therapeutic range (50-100mg/l) and exhibits nonlinear protein binding. Additionally, VPA pharmacokinetics are dependent on age, induction status, formulation; so titration dosing vary between individuals. The aim of these simulations was to determine optimal intravenous (i.v.) loading dose, i.v. oral maintenance regimens. A 5-min 15mg/kg dose resulted in total free plasma concentrations approximately 65 7.5mg/l children, 80 11mg/l adults, 1h after the infusion; status had little effect. For uninduced children 7.5 3.5mg/kg q6h valproate sodium, initiated 6h maintains concentrations. rapid decline following an combination with delayed initial absorption drug from delayed-release divalproex sodium tablets warrant beginning q12h regimens within 2h population. Plasma can be sustained using once-daily extended-release if concurrently two-fold higher regimen may required induced patients.