Every-12-hour administration of extended-release divalproex in patients with epilepsy: Impact on plasma valproic acid concentrations

作者: Ronald C. Reed , Sandeep Dutta , John H. Cavanaugh , Charles Locke , G. Richard Granneman

DOI: 10.1016/J.YEBEH.2005.12.004

关键词:

摘要: Extended-release divalproex sodium (divalproex-ER) biopharmaceutics after every-12-hour (q12h) administration was compared with that of once-daily divalproex-ER and conventional given every 6 hours (q6h) in a multiple-dose (14-day), randomized, three-period crossover design study 24 patients epilepsy concomitantly receiving enzyme-inducing antiepileptic medication(s). Plasma valproic acid (VPA) minimum concentration (Cmin) for q12h higher than the Cmin (P=0.043). Once-daily values were not different from those q6h, suggesting adequate trough steady-state concentrations are maintained once daily dosing, despite comedication. The degree peak-trough fluctuation (DFL, calculated as (Cmax-Cmin)/Cavg) VPA less both (35.2% less) (16.9% regimens q6h (P0.024). DFL dosed regimen 22% (P=0.02). can be minimized more so administration, enteric-coated taken q6h.

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