Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium.

摘要: Objectives: To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium. Methods: Prospective evaluation of consecutive adult outpatients at an urban public hospital who were followed for 6 months drug formulations. Seizure frequency was estimated patient self-reports. Medication monitored with a structured interview (tremor, fatigue, GI upset, hair loss), physician exam (nystagmus, tremor), drawing test (tremor) specific 25-item questionnaire assessing the impact tremor on activities daily living. Results: Forty-seven included study but six either lost follow-up or had insufficient data. side-effect profile did not change significantly However, significant subjective improvement their as assessed by (p = 0.009 3 p 0.04 months); other measures severity showed no during 6-month period. Most (71%) preferred formulation. Conclusion: Patients epilepsy can be switched standard sodium, without profile. prefer formulation, part due decrease activities.