Conversion from delayed-release sodium valproate to extended-release sodium valproate: Initial results and long-term follow-up
作者： Paul H. McCabe , Nancy C. Michel , Cathy D. McNew , Erik B. Lehman
DOI: 10.1016/J.YEBEH.2006.02.006
关键词:
摘要: Abstract Objective The goal of our study was to evaluate clinical and serum valproic acid concentration changes in patients following overnight conversion from delayed-release sodium valproate (VPA-DR) the same daily dosage extended-release (VPA-ER). Methods Epilepsy on VPA-DR were offered chance convert VPA-ER. Thirty converted twice-daily dosing 11 once-daily dosing. Trough levels measured prior change 2 weeks after conversion. Short-term long-term data evaluated. Results Patients successfully VPA DR No significant difference percentage trough level observed when comparing frequency VPA-DR, total VPA, versus VPA-ER, or presence enzyme-inducing agents. Mean seizure count per month 3.35 3.29 Improvements tremor, weight gain, nausea/vomiting noted. Conclusions Overnight VPA-ER well tolerated by all patients. Long-term results favorable, with 77.5% remaining drug. Seizure counts adverse events remained improved both short-term evaluations. Dosing either is acceptable.
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sci-hub.se 参考文章(10)
Sandeep Dutta, Ronald C. Reed, John H. Cavanaugh, Absolute Bioavailability and Absorption Characteristics of Divalproex Sodium Extended-Release Tablets in Healthy Volunteers The Journal of Clinical Pharmacology. ,vol. 44, pp. 737- 742 ,(2004) , 10.1177/0091270004266782
Joyce A. Cramer, How Often Is Medication Taken as Prescribed? JAMA. ,vol. 261, pp. 3273- 3277 ,(1989) , 10.1001/JAMA.1989.03420220087032
Lydia Kernitsky, Kathryn A. O'Hara, Ping Jiang, John M. Pellock, Extended-release divalproex in child and adolescent outpatients with epilepsy. Epilepsia. ,vol. 46, pp. 440- 443 ,(2005) , 10.1111/J.0013-9580.2005.39804.X
Kenneth W Sommerville, Sandeep Dutta, Victor Biton, Yiming Zhang, James C Cloyd, Basim Uthman, Bioavailability of a Divalproex Extended-Release Formulation versus the Conventional Divalproex Formulation in Adult Patients Receiving Enzyme-Inducing Antiepileptic Drugs. Clinical Drug Investigation. ,vol. 23, pp. 661- 670 ,(2003) , 10.2165/00044011-200323100-00005
Sandeep Dutta, Yiming Zhang, Daniel S. Selness, Lillian L. Lee, Laura A. Williams, Kenneth W. Sommerville, Comparison of the bioavailability of unequal doses of divalproex sodium extended-release formulation relative to the delayed-release formulation in healthy volunteers. Epilepsy Research. ,vol. 49, pp. 1- 10 ,(2002) , 10.1016/S0920-1211(02)00007-4
Hiroyuki Shimizu, Surgical Treatment of Frontal Lobe Epilepsy Epilepsia. ,vol. 38, pp. 54- 57 ,(1997) , 10.1111/J.1528-1157.1997.TB00108.X
R.de Wit, F.S.A.M.van Dam, A.van Buuren, C.van der Heijden, How often is medication taken as prescribed? European Journal of Cancer. ,vol. 29, pp. S260- ,(1993) , 10.1016/0959-8049(93)92083-5
Manon Thibault, Warren T Blume, Jean-Marc Saint-Hilaire, Rafik Zakhari, Kenneth W Sommerville, Divalproex extended-release versus the original divalproex tablet: results of a randomized, crossover study of well-controlled epileptic patients with primary generalized seizures. Epilepsy Research. ,vol. 50, pp. 243- 249 ,(2002) , 10.1016/S0920-1211(02)00048-7
Michael C. Smith, Franca Centorrino, Jeffrey A. Welge, Michelle A. Collins, Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials Epilepsy & Behavior. ,vol. 5, pp. 746- 751 ,(2004) , 10.1016/J.YEBEH.2004.07.007
J. A. Cramer, How often is medication taken as prescribed? A novel assessment technique JAMA: The Journal of the American Medical Association. ,vol. 261, pp. 3273- 3277 ,(1989) , 10.1001/JAMA.261.22.3273