Electrical stimulation of superior colliculus affects strabismus angle in monkey models for strabismus

摘要: Disruption of binocular vision during the critical period for development leads to eye misalignment in humans and monkey models. We have previously suggested that disruption within a vergence circuit could be neural basis strabismus. Electrical stimulation rostral superior colliculus (rSC) movements normal monkeys. Therefore, purpose this study was investigate effect SC on strabismic delivered 51 sites intermediate deep layers (400 Hz, 0.5-s duration, 10-40 μA) 3 adult optical prism-reared Scleral search coils were used measure both eyes fixation task. Staircase saccades with horizontal vertical components elicited by as predicted from topographic map. also resulted significant changes strabismus angle, i.e., shift toward exotropia/esotropia depending site. Electrically evoked saccade vector amplitude two not significantly different (P > 0.05; paired t-test) but direction differed. However, disconjugacy accounted only ~50% change while disconjugate postsaccadic other due electrical stimulation. In summary, our data suggest monkeys produces alignment is combination saccadic movements.NEW & NOTEWORTHY results misalignment. These support notion developmental circuits leading maintenance