作者: Du Young Ko , Usha Pramod Shinde , Bora Yeon , Byeongmoon Jeong
DOI: 10.1016/J.PROGPOLYMSCI.2012.08.002
关键词: Drug delivery 、 Tissue engineering 、 PLGA 、 In situ 、 Self-healing hydrogels 、 Stem cell 、 Nanotechnology 、 Scaffold 、 Poloxamer 、 Materials science
摘要: With the rapid progress of biomedical technology, hydrogels that can be prepared under bio-friendly conditions are urgently needed. In situ gelling systems have been extensively investigated with the aim of being applied for minimally invasive drug delivery or injectable tissue engineering. In a premixed state of an aqueous solution, the system contains drugs or cells and other excipients. Chemical or physical triggering processes produce a hydrogel in situ. During the solution-to-gel transition process, all of the ingredients in the system form a …