Recent progress of in situ formed gels for biomedical applications

作者: Du Young Ko , Usha Pramod Shinde , Bora Yeon , Byeongmoon Jeong

DOI: 10.1016/J.PROGPOLYMSCI.2012.08.002

关键词: Drug deliveryTissue engineeringPLGAIn situSelf-healing hydrogelsStem cellNanotechnologyScaffoldPoloxamerMaterials science

摘要: With the rapid progress of biomedical technology, hydrogels that can be prepared under bio-friendly conditions are urgently needed. In situ gelling systems have been extensively investigated with the aim of being applied for minimally invasive drug delivery or injectable tissue engineering. In a premixed state of an aqueous solution, the system contains drugs or cells and other excipients. Chemical or physical triggering processes produce a hydrogel in situ. During the solution-to-gel transition process, all of the ingredients in the system form a …

参考文章(241)
Xing Liu, Lie Ma, Zhengwei Mao, Changyou Gao, Chitosan-Based Biomaterials for Tissue Repair and Regeneration Springer, Berlin, Heidelberg. pp. 81- 127 ,(2011) , 10.1007/12_2011_118
Takashi Miyata, Noriko Asami, Tadashi Uragami, A reversibly antigen-responsive hydrogel Nature. ,vol. 399, pp. 766- 769 ,(1999) , 10.1038/21619
Jenny A. Cadée, Mies J. van Steenbergen, Cees Versluis, Albert J. R. Heck, Willy J. M. Underberg, Willem den Otter, Wim Jiskoot, Wim E. Hennink, Oxidation of recombinant human interleukin-2 by potassium peroxodisulfate. Pharmaceutical Research. ,vol. 18, pp. 1461- 1467 ,(2001) , 10.1023/A:1012213108319
Guanghui Yang, Ladan Espandar, Nick Mamalis, Glenn D. Prestwich, A cross-linked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits Veterinary Ophthalmology. ,vol. 13, pp. 144- 150 ,(2010) , 10.1111/J.1463-5224.2010.00771.X
Aleksander Skardal, Jianxing Zhang, Lindsi McCoard, Xiaoyu Xu, Siam Oottamasathien, Glenn D. Prestwich, Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting Tissue Engineering Part A. ,vol. 16, pp. 2675- 2685 ,(2010) , 10.1089/TEN.TEA.2009.0798
Ryan McLemore, Stephanie A. Robb, Bae Hoon Lee, Michael R. Caplan, Brent L. Vernon, Michael-Type Addition Reactions in NIPAAm-Cysteamine Copolymers Follow Second Order Rate Laws with Steric Hindrance Annals of Biomedical Engineering. ,vol. 37, pp. 2416- 2425 ,(2009) , 10.1007/S10439-009-9776-0
Song P. Seto, Maria E. Casas, Johnna S. Temenoff, Differentiation of mesenchymal stem cells in heparin-containing hydrogels via coculture with osteoblasts. Cell and Tissue Research. ,vol. 347, pp. 589- 601 ,(2012) , 10.1007/S00441-011-1265-8
Ying Zhang, Wen Zhu, Biaobing Wang, Jiandong Ding, A novel microgel and associated post-fabrication encapsulation technique of proteins. Journal of Controlled Release. ,vol. 105, pp. 260- 268 ,(2005) , 10.1016/J.JCONREL.2005.04.001
Byeongmoon Jeong, Sung Wan Kim, You Han Bae, Thermosensitive sol-gel reversible hydrogels. Advanced Drug Delivery Reviews. ,vol. 54, pp. 37- 51 ,(2002) , 10.1016/S0169-409X(01)00242-3