METHOD OF TREATING OPHTHALMIC DISORDERS USING TGF-$g(b)
作者： Ann F. Hanham , Bert M. Glaser , Bruce B. Pharriss , George A. Ksander
DOI:
关键词: Macular degeneration 、 Tears 、 Cataracts 、 Transforming growth factor 、 Ophthalmology 、 Retinal detachment 、 Medicine 、 OPHTHALMIC DISORDERS
摘要: This invention is a method for the treatment of ophthalmic disorders. The suitable variety disorders including macular holes, degeneration, and retinal detachment tears, cataracts, corneal scleral injuries. entails application an effective amount Transforming Growth Factor-β (TGF-β) to affected region.
lens.org参考文章(31)
S Eldridge, E S Hilderbrand, L Feeney-Burns, Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Investigative Ophthalmology & Visual Science. ,vol. 25, pp. 195- 200 ,(1984)
R. Derynck, P. B. Lindquist, A. Lee, D. Wen, J. Tamm, J. L. Graycar, L. Rhee, A. J. Mason, D. A. Miller, R. J. Coffey, A new type of transforming growth factor-beta, TGF-beta 3. The EMBO Journal. ,vol. 7, pp. 3737- 3743 ,(1988) , 10.1002/J.1460-2075.1988.TB03257.X
P A Campochiaro, K H Leschey, S F Hackett, J H Singer, Growth factor responsiveness of human retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. ,vol. 31, pp. 839- 846 ,(1990)
A M Schor, S F Elstow, J B Weiss, Bovine retinal angiogenesis factor is a small molecule (molecular mass less than 600). Investigative Ophthalmology & Visual Science. ,vol. 26, pp. 74- 79 ,(1985)
S C Chen, C H Chen, Angiogenic activity of vitreous and retinal extract. Investigative Ophthalmology & Visual Science. ,vol. 19, pp. 596- 602 ,(1980)
S.M. Seyedin, P.R. Segarini, D.M. Rosen, A.Y. Thompson, H. Bentz, J. Graycar, Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 262, pp. 1946- 1949 ,(1987) , 10.1016/S0021-9258(18)61601-1
R A Ignotz, J Massagué, Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. Journal of Biological Chemistry. ,vol. 261, pp. 4337- 4345 ,(1986) , 10.1016/S0021-9258(17)35666-1
Stella M Robertson, Herman M Kunkle Jr, Michael E Stern, Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation ,(1990)
David R. Gibson, Methods and materials for use in corneal wound healing ,(1990)
Edward P Amento, L Steven Beck, None, Method of predisposing mammals to accelerated tissue repair ,(1991)