Role of the renin-angiotensin system in the nandrolone-decanoate-induced attenuation of the Bezold-Jarisch reflex.
作者： Tadeu Uggere de Andrade , Leonardo Zanoteli Loiola , Samira Merces Nascimento Alcure , Ana Raquel Santos Medeiros , Maria Carmen Lopes Ferreira Silva Santos
DOI: 10.1139/Y11-090
关键词: Enalapril 、 Renin–angiotensin system 、 Nandrolone 、 Reflex 、 Mean arterial pressure 、 Endocrinology 、 Muscle hypertrophy 、 Bradycardia 、 Chemistry 、 Bezold–Jarisch reflex 、 Internal medicine
摘要: The androgen nandrolone decanoate (ND) is known to cause cardiovascular abnormalities, such as attenuation of the Bezold–Jarisch Reflex (BJR), cardiac hypertrophy, and elevation mean arterial pressure (MAP). Futhermore, a relationship between androgens renin–angiotensin system (RAS) has been reported. purpose this study was evaluate influence RAS on BJR, prostatic MAP evoked by ND. For this, male Wistar rats were treated with ND (10 mg·(kg body mass)–1 for 8 weeks; DECA), or vehicle (control animals; CON), enalapril mass)–1, daily; CONE), (10 mg + 10 mg per kilogram mass; DECAE). After 8 weeks treatment, BJR evaluated bradycardia hypotensive responses that elicited serotonin administration (2–32 µg·(kg mass)–1). assessed; prostate hypertrophy determined ratio tissue mass:body mass, histological analysis ...
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