The effect of vitamin D prophylaxis on radiation induced pulmonary damage.
作者： Gozde YAZICI , Ferah YILDIZ , Alper ISKIT , Esra ERDEMLI , Selcuk SURUCU
DOI: 10.1269/JRR.11033
关键词: Radiation therapy 、 In vivo 、 Vascular permeability 、 Fibrosis 、 Vitamin D and neurology 、 Chemistry 、 Vitamin 、 In vitro 、 Pulmonary toxicity 、 Pathology
摘要: Vitamin D/Fibrosis/Radiation pneumonia/Electron microscopy. D has a selective radio and chemosensitizing effect on tumor cells. In vitro in vivo studies have shown that vitamin inhibits collagen gel construction, induces type II pneumocyte proliferation an d surfactant synthesis the lungs, decreases vascular permeability caused by radiation. The aim of this experimental study was to determine if protective against radiation-induced pulmonary damage. Adult Wistar rats were divided into 4 groups. Group 1 comprised control animals. 2, which administered 0.25 μg/ kg/day D3 for 8 weeks, group. Rats groups 3 given 20 Gy right hemithorax radiotherapy, addition group treatment, began day before radiotherapy continued weeks. At th 12 weeks from each sacrificed. Right lungs dissected light electron microscopic study. microscopy examinations revealed statistically significant differences between 4, there less interstitial inflammation deposition, alveolar structu re cells lining walls protected. These results confirm pro tective toxicity. findings should be evaluated with further clinical studies.
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