Effect of the vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal human fibroblasts
作者： Mark K. Polar , Chris Gennings , Misook Park , Mona S. Gupta , David A. Gewirtz
DOI: 10.1007/S00280-003-0606-Z
关键词:
摘要: Purpose Previous work from this laboratory has demonstrated that the vitamin D3 analogs EB 1089 and ILX 23-7553 enhance response of breast tumor cells to ionizing radiation promote radiation-induced apoptotic cell death. The current studies were designed more closely simulate clinical radiotherapy in treatment cancer by examining utility as an adjunct fractionated radiation. potential toxicity normal tissue combination was assessed a model BJ human fibroblasts culture.
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