Noninvasive nucleic acid-based approaches to monitor placental health and predict pregnancy-related complications.

摘要: During pregnancy, the placenta releases a variety of nucleic acids (including deoxyribonucleic acid, messenger ribonucleic or microribonucleic acids) either as result cell turnover an active messaging system between and cells in maternal body. The profile released changes with gestational age has been associated fetal parameters. It also can directly reflect pathological placenta. Nucleic may therefore provide rich source novel biomarkers for prediction pregnancy complications. However, their utility clinical setting depends, first, on overcoming some technical considerations quantification, and, second, developing better understanding factors that influence function abundance.