Fetal microchimerism by mode of delivery: a prospective cohort study.

摘要: Objective To compare fetal microchimerism (FMc) in pregnancies with uncomplicated vaginal delivery (VD) versus caesarean (CD). Design Prospective cohort study. Setting University of Washington and Fred Hutchinson Cancer Research Center, USA. Population Women delivering singleton without pertinent antenatal complications deliveries (n = 36). Methods We collected maternal predelivery, postdelivery umbilical cord blood for each mother-baby pair. Following genotyping, FMc was measured quantitative polymerase chain reaction assays targeting fetus-specific polymorphisms. Quantification is expressed as genome equivalents (gEq) DNA/100 000 total gEq tested. detection evaluated by logistic regression while controlling number cell tested clinically relevant covariates. concentrations were compared using negative binomial the same covariates predelivery positivity. Main outcome measure Detection concentration mode delivery. Results Twenty-four pairs had a VD 12 CD. Postdelivery higher following CD than after (58.3% 16.7%, P 0.02). After covariates, likelihood almost nine-fold (odds ratio 8.8, 95% CI 1.6-47.6; 0.01). With respect to concentration, rate adjusted model 14.7 (95% 3.2-66.8; 0.001). Conclusion peripheral are significantly VD. As associated long-term health, our findings suggest that may impact this risk. Tweetable abstract Greater found