Effective Controlled Release of Captopril by Silylation of Mesoporous MCM‐41
作者： Fengyu Qu , Guangshan Zhu , Shiying Huang , Shougui Li , Shilun Qiu
关键词: Mesoporous material 、 Inorganic chemistry 、 Silylation 、 Infrared spectroscopy 、 Magic angle spinning 、 Controlled release 、 Chemistry 、 Chemical engineering 、 Mesoporous silica 、 MCM-41 、 Adsorption
摘要: The release of the water-soluble drug Captopril is controlled by tailoring surface properties mesoporous silica via stepwise silylation. degree silylation manipulated adjusting initial concentration silylanizing reagent (trimethylchlorosilane, TMCS). silylanized and drug-loaded samples are characterized powder X-ray diffraction, Fourier transform IR spectroscopy, N2 adsorption desorption,29Si cross-polarization magic angle spinning NMR transmission electron microscopy. drug-loading amount correlated to Brunauer–Emmett–Teller area hydrophilicity/hydrophobicity material, while profiles can be pore size.
sci-hub.se 参考文章(36)
A. Rámila, B. Muñoz, J. Pérez-Pariente, M. Vallet-Regí, Mesoporous MCM-41 as Drug Host System Journal of Sol-Gel Science and Technology. ,vol. 26, pp. 1199- 1202 ,(2003) , 10.1023/A:1020764319963
P. Horcajada, A. Rámila, J. Pérez-Pariente, M. Vallet-Regı́, Influence of pore size of MCM-41 matrices on drug delivery rate Microporous and Mesoporous Materials. ,vol. 68, pp. 105- 109 ,(2004) , 10.1016/J.MICROMESO.2003.12.012
Corine Tourné-Péteilh, Daniel Brunel, Sylvie Bégu, Bich Chiche, François Fajula, Dan A. Lerner, Jean-Marie Devoisselle, Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel New Journal of Chemistry. ,vol. 27, pp. 1415- 1418 ,(2003) , 10.1039/B307046H
Corine Tourné-Péteilh, Dan A. Lerner, Clarence Charnay, Lionel Nicole, Sylvie Bégu, Jean-Marie Devoisselle, The potential of ordered mesoporous silica for the storage of drugs: the example of a pentapeptide encapsulated in a MSU-tween 80. ChemPhysChem. ,vol. 4, pp. 281- 286 ,(2003) , 10.1002/CPHC.200390045
Dong-Huy Park, Norikazu Nishiyama, Yasuyuki Egashira, Korekazu Ueyama, Enhancement of Hydrothermal Stability and Hydrophobicity of a Silica MCM-48 Membrane by Silylation Industrial & Engineering Chemistry Research. ,vol. 40, pp. 6105- 6110 ,(2001) , 10.1021/IE0103761
J. S. Beck, J. C. Vartuli, W. J. Roth, M. E. Leonowicz, C. T. Kresge, K. D. Schmitt, C. T. W. Chu, D. H. Olson, E. W. Sheppard, S. B. McCullen, J. B. Higgins, J. L. Schlenker, A new family of mesoporous molecular sieves prepared with liquid crystal templates Journal of the American Chemical Society. ,vol. 114, pp. 10834- 10843 ,(1992) , 10.1021/JA00053A020
Takeru Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension Journal of Pharmaceutical Sciences. ,vol. 50, pp. 874- 875 ,(1961) , 10.1002/JPS.2600501018
Ekkehard Lindner, Theodor Schneller, Friedrich Auer, Hermann A. Mayer, Chemie in Interphasen – ein neuer Weg für die metallorganische Synthese und Katalyse Angewandte Chemie. ,vol. 111, pp. 2288- 2309 ,(1999) , 10.1002/(SICI)1521-3757(19990802)111:15<2288::AID-ANGE2288>3.0.CO;2-A
Hong-liang Li, Nina Perkas, Qiao-ling Li, Yossi Gofer, Yuri Koltypin, Aharon Gedanken, Improved Silanization Modification of a Silica Surface and Its Application to the Preparation of a Silica-Supported Polyoxometalate Catalyst Langmuir. ,vol. 19, pp. 10409- 10413 ,(2003) , 10.1021/LA035280L
Cheng-Yu Lai, Brian G. Trewyn, Dusan M. Jeftinija, Ksenija Jeftinija, Shu Xu, Srdija Jeftinija, Victor S.-Y. Lin, A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. Journal of the American Chemical Society. ,vol. 125, pp. 4451- 4459 ,(2003) , 10.1021/JA028650L