Mesoporous MCM-41 as Drug Host System
作者： A. Rámila , B. Muñoz , J. Pérez-Pariente , M. Vallet-Regí
关键词: MCM-41 、 Mesoporous material 、 Siloxane 、 Drug delivery 、 Chemical engineering 、 Chemistry 、 Organic chemistry 、 Molecular sieve 、 Silanol 、 Molecule 、 Drug carrier
摘要: Among the large number of applications mesoporous MCM-41 materials, we have recently developed their new use as drug delivery system. Since this kind materials consist on a disordered network siloxane bridges and free silanol groups, these latter could be reacting sites against appropriate guest chemical species. In work, application system has been studied from host-guest interaction point view. Two factors affect that interaction: structure pore wall surface, functional groups present in organic molecule. Hence, two approaches performed: functionalising changing drug.
springer.com
sci-hub.se 参考文章(4)
Karin Moller, Thomas Bein, Inclusion Chemistry in Periodic Mesoporous Hosts Chemistry of Materials. ,vol. 10, pp. 2950- 2963 ,(1998) , 10.1021/CM980243E
M. Vallet-Regi, A. Rámila, R. P. del Real, J. Pérez-Pariente, A New Property of MCM-41: Drug Delivery System Chemistry of Materials. ,vol. 13, pp. 308- 311 ,(2001) , 10.1021/CM0011559
Jackie Y. Ying, Christian P. Mehnert, Michael S. Wong, Synthesis and Applications of Supramolecular-Templated Mesoporous Materials Angewandte Chemie International Edition. ,vol. 38, pp. 56- 77 ,(1999) , 10.1002/(SICI)1521-3773(19990115)38:1/2<56::AID-ANIE56>3.0.CO;2-E
Peidong Yang, † Gernot Wirnsberger, Howard C Huang, Steven R Cordero, Michael D McGehee, Brian Scott, Tao Deng, George M Whitesides, Bradley F Chmelka, Steven K Buratto, Galen D Stucky, Mirrorless lasing from mesostructured waveguides patterned by soft lithography Science. ,vol. 287, pp. 465- 467 ,(2000) , 10.1126/SCIENCE.287.5452.465