Staphylococcal and Streptococcal Superantigens: an Update

摘要: This chapter provides an introduction to bacterial superantigen (SAg) and presents the current understanding of disease association causation by SAgs, with intent identifying needed future research studies SAgs. Bacterial SAgs include those produced β-hemolytic streptococci (including Streptococcus pyogenes), aureus intermedius, Mycoplasma arthritidis, certain species Yersinia. In authors consider only T-cell SAgs; definitions listed may be easily adapted define B-cell The pyrogenic toxin staphylococcal enterotoxins (SEs), which are known cause emesis when administered orally monkeys, thus causes food poisoning. Streptococcal exotoxins (SPEs) (erythrogenic toxins, scarlet fever toxins) now classic SPEs A C, but also serotypes G, H, I, J, K, L, M, streptococcal (SSA), mitogenic exotoxin Zn (SMEZ). last aspect author's presentation new horizons for SAg is based on premise that human diseases caused begin their interaction epithelial cells. Both group S. infections skin mucous membranes and, most these organisms make Clearly, additional necessary clarify all aspects mucosal surfaces. These likely more fully extent involvement in illnesses, at same time characterize mechanism penetration