Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis.
作者： A. Stutzin , E. K. Hoffmann
DOI: 10.1111/J.1748-1716.2006.01537.X
关键词: Apoptosis 、 Cell growth 、 Cell biology 、 Programmed cell death 、 Ion channel 、 Chloride channel 、 Hypotonic Stress 、 Cytoskeleton 、 Biochemistry 、 Chemistry 、 Homeostasis
摘要: Cell volume regulation is one of the most fundamental homeostatic mechanisms and essential for normal cellular function. At same time, however, many physiological are associated with regulatory changes in cell size meaning that set point under control. Thus, a tight dynamic control abnormal will ultimately lead to severe dysfunction, including alterations proliferation death. This review describes different swelling-activated ion channels participate as key players maintenance steady-state volume, particular emphasis on intracellular signalling pathways responsible their during hypotonic stress, apoptosis.
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