Refinement of the Avian Oncornavirus-Induced Primary Rat Brain Tumor Model for Therapeutic Screening

摘要: The relevance of animal models for human disease is a topic often hotly debated by experimentalists, especially when the model to be used evaluate unproven and potentially hazardous therapeutic innovations prior initial clinical investigation. For decades general oncologists (1, 2) have argued use primary, autochthonous tumors rather than transplanted on basis 1) potential or proven differences between tumor host histocompatibility antigens; possibility contamination virus mycoplasma during transplant; 3) selection cells serial transplantation possessing growth properties unlike those primary tumors. Moreover, neuro-oncologists (3, 4, 5) felt that most brain differed greatly from histological type serious problem, glioblastoma multiforme — anaplastic astrocytoma group, blood supply blood-brain barrier alterations were markedly different in Nevertheless, majority trials models, both chemotherapeutic immunotherapeutic, been conducted with (6–20). One commonly murine tumors, an ependomyoblastoma, was induced over 30 years ago now expressing large amounts infectious mammary (21).