Signaling lymphocyte activation molecule regulates development of colitis in mice.

摘要: Background & Aims Signaling lymphocyte activation molecule (Slamf)1 is a co-stimulatory receptor on T cells and regulates cytokine production by macrophages dendritic cells. Slamf1 microbicidal mechanisms in macrophages, therefore we investigated whether the affects development of colitis mice. Methods We transferred CD45RB hi CD4 + into Rag −/− or mice to induce colitis. also induced injecting with an antibody that activates CD40. determined severity enterocolitis based disease activity index, histology scores, levels production, assessed effects antibodies against induction. quantified migration monocytes macrophage inflamed tissues upon induction thioglycollate-induced peritonitis response tumor necrosis factor-α air-pouch model leukocyte migration. Results Colitis was reduced mice, compared after transfer administration CD40 agonist. The numbers were other inflammatory disorders. An inhibited level Conclusions contributes It appears indirectly regulate appearance intestinal tissues. Antibodies inhibit reduce so human SLAMF1 might be therapeutic target for bowel disease.