Dietary calcium and blood pressure in experimental models of hypertension. A review.

摘要: More than 80 studies have reported lowered blood pressure after dietary calcium enrichment in experimental models of hypertension. The evidence presented here suggests that may act concurrently through a number physiological mechanisms to influence pressure. importance any given mechanism vary depending on the model under consideration. Supplemental is associated with reduced membrane permeability, increased Ca(2+)-ATPase and Na,K-ATPase, intracellular calcium. These results suggest supplemental limit influx into cell improve ability VSMC extrude This could be direct effect or an indirect mediated hormonally. calcium-regulating hormones all been found vasoactive properties therefore Furthermore, CGRP proposed parathyroid hypertensive factor are both substances responsive Therefore, diet-induced variations Modulation sympathetic nervous system another important way can There altered norepinephrine levels hypothalamus as consequence manipulations well changes central outflow. Dietary has also shown specifically modify alpha 1-adrenergic receptor activity periphery. In some hypertension, alter by changing metabolism other electrolytes. For example, prevent sodium chloride-induced elevations attributed natriuresis. However, natriuresis does not account for interactive effects chloride Sodium hypertension due part wasting subsequent elevation hormones. Chloride mediator this because it appears cause when combined chloride. attention needed. Not only itself neural function, but many appear affect system. implications regulation extend aspects physiology behavior.