β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex

摘要: Mice that lack all beta1-class integrins in neurons and glia die prematurely after birth with severe brain malformations. Cortical hemispheres cerebellar folia fuse, cortical laminae are perturbed. These defects result from disorganization of the marginal zone, where regulate glial endfeet anchorage, meningeal basement membrane remodeling, formation Cajal-Retzius cell layer. Surprisingly, not essential for neuron-glia interactions neuronal migration during corticogenesis. The phenotype beta1-deficient mice resembles pathological changes observed human dysplasias, suggesting defective integrin-mediated signal transduction contributes to development some these diseases.