Rôle du laboratoire d’anatomie pathologique dans l’approche pré-analytique des examens de biologie moléculaire réalisés en pathologie tumorale

摘要: The advent of the targeted cancer therapies administered to patients, according results molecular biology techniques (in particular, in situ hybridization, "polymerase chain reaction" amplification and sequencing), has modified practice surgical pathology laboratories. necessity answer needs physicians for optimizing medical care patients who develop led a policy national debate, spurred by National Institute Cancer (INCa), order implement new procedures Thus, addition structuring platforms their labeling INCa, upstream control steps present between resection tumor samples analysis proved be crucial. Indeed, quality this time, called "pre-analytical" phase, determines reliability therefore therapeutic strategy. We describe here main checked pre-analytical phase. optimization phase within laboratory aims reduce or render insignificant risk errors tests. These can indeed lead false negative positive whose consequences particularly harmful with cancer.