Body size phenotypes and inflammation in the Women's Health Initiative Observational Study.

摘要: Individuals with “metabolically benign” obesity (obesity unaccompanied by hypertension, dyslipidemia, and diabetes) are not at elevated 10-year risk of cardiovascular disease compared to normal weight individuals. It remains unclear whether these obese individuals or clustering cardiometabolic factors display heightened immune activity. Therefore, we characterized levels acute phase reactants (CRP, IL-6, TNF-alpha, white blood cell count), adhesion molecules (E-selectin, VCAM-1), coagulation products (fibrinogen, PAI-1) among four body size phenotypes (normal 0/1 vs. ≥2 metabolic syndrome components/diabetes overweight/obesity components/diabetes) in cross-sectional analyses 1,889 post-menopausal women from the Women’s Health Initiative Observational Study nested case-control stroke study. Higher all three inflammatory marker categories were found components diabetes. Compared 0 1 components, diabetes more likely have ≥3 markers top quartile (multivariate odds ratio [OR] 2.0, 95% CI: 1.3–3.0), as overweight/obese (OR 2.3; CI:1.5–3.5). Overweight/obese had highest 4.2; 2.9–5.9). Despite findings that metabolically benign increased individuals, current results suggest without still possess abnormal markers.