Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

摘要: Background: A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role the pathological process acute coronary syndrome (ACS). However, results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine relationship between and ACS. Methods results: We screened PubMed/MEDLINE, EBSCIO, EMBASE research reports until Mar. 2014 extracted data from 10 involving 6102 ACS patients 8669 controls. Subgroup analysis by ethnicity documented significant decreased risk for Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64–0.83), dominant model (OR 0.71; CI 0.62–0.82), homozygote 0.57; 0.35–0.92). overall especially with Caucasians, no association was uncovered. Further meta-regression revealed heterogeneity among largely attributed ethnicity. No publication bias detected through funnel plot Egger’s linear regression test. Conclusions: Taken together, our suggest might be protective factor against developing population. researches will needed identify confounding factors which modified effect T allele Caucasians.