Cumulative effect of oxidative stress-related gene polymorphisms on myocardial infarction in type 2 diabetes.
作者： N. Katakami , K. Sakamoto , H. Kaneto , M. Matsuhisa , K. Ohno
DOI: 10.2337/DC08-0237
关键词:
摘要: It is well-known that oxidative stress plays critical roles in the pathogenesis of atherosclerotic diseases. In this study, we examined association between four common genetic variants related to (glutamate-cysteine ligase modifier subunit (GCLM) C-588T, myeloperoxidase G-463A, human paraoxonase-1 Gln192Arg, and NADPH oxidase p22phox C242T) prevalence myocardial infarction type 2 diabetic patients. All patients who periodically attended outpatient diabetes clinics five participating hospitals were asked participate study. Subjects eligible had diabetes, diagnosed by diabetologists based on World Health Organization criteria, aged ≥50 years. A total 2,561 subjects included: men, 62%; age, mean ± SD 60.9 …
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