The influence of gender, age and treatment time on brain oxidative stress and memory impairment induced by D-galactose in mice.

摘要: Chronic exposure to d-galactose (d-gal) serves as a model for age-related oxidative damage and cognitive dysfunction. However, methods used, including the dose treatment time of d-gal well gender, age strain animals vary greatly among published articles. In this study, we investigate effect on brain stress spatial memory deficits induced by in mice, respectively. Eight-week-old female mice injected with 100mg/kg per day, 6 weeks, did not show impairment or high levels hydroxyl radical, protein carbonyl malondialdehyde homogenates, although reactive oxygen species were increased when compared saline control mice. contrast, both 8-week-old male 24-week-old receiving 10 weeks showed significant increases above markers, their corresponding controls. These results demonstrate that d-gal-induced are dependent upon d-gal, plus gender used. The findings can serve useful guide successfully establishing models.