Chronic systemic injection of D-galactose impairs the septohippocampal cholinergic system in rats
作者： Ming Lei , Yang Su , Xiangdong Hua , Jiong Ding , Qunying Han
DOI: 10.1097/WNR.0B013E3283136A1F
关键词:
摘要: Accumulated evidence indicates chronic systemic injection of D-galactose mimics aging progress induced by oxidative stress. We addressed whether memory impairment in this model was associated with the cholinergic septohippocampal degeneration. Rats injected for 6 weeks showed spatial learning and as measured water maze test. Correspondingly, anti-choline acetyltransferase immunohistochemistry demonstrated a severe loss terminals hippocampus accompanied mild neuronal atrophy medial septum nucleus vertical limb diagonal band Broca. A major synaptic degeneration confirmed ultrastructural analysis. These findings provide neuropathological rodents promising brain age-related neurodegeneration.
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