Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
作者： Chuanzhao Zhang , Debangshu Samanta , Haiquan Lu , John W. Bullen , Huimin Zhang
关键词: Cancer stem cell 、 Homeobox protein NANOG 、 MRNA methylation 、 Hypoxia-inducible factors 、 Nanog Homeobox Protein 、 Molecular biology 、 MRNA modification 、 Gene knockdown 、 Biology 、 Cell biology 、 Rex1
摘要: … We show that inhibiting the expression of AlkB homolog 5 (ALKBH5), which demethylates m 6 A, or the hypoxia-inducible factors (HIFs) HIF-1α and HIF-2α, which activate ALKBH5 gene …
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