Kinetics of trabecular bone resorption and formation in hypothyroidism: Evidence for a positive balance per remodeling cycle

摘要: Using a recently described model for reconstruction of the entire remodeling sequence in trabecular bone after tetracycline double labeling, was investigated 18 hypothyroid female patients and 11 age- sex-matched controls. In group, final resorption depth reduced to 42 microns vs 53 control group (P less than 0.01). The total period increased 76 days 32 0.001), rate lowered 0.8 micron/day 2.1 microns/day 0.001). function preosteoblast-like cells 22 compared 14 normals 0.05). formation prolonged 620 151 matrix mineral appositional rates were 0.7 0.5 micron3/micron2 per day 1.8 0.001) 1.4 day, respectively. mineralization lag time 48 25 at start this difference even more pronounced (63 16 days, respectively, P mean completed wall thickness 59.5 54 micron 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)