In vivo visualization of pituitary dopaminergic receptors by iodine-123 methoxybenzamide (IBZM) correlates with sensitivity to dopamine agonists in two patients with macroprolactinomas.

摘要: We performed in two patients with macroprolactinoma, pituitary scintigraphy 123 iodine-methoxybenzamide (IBZM), a dopaminergic antagonist that specifically binds to the D2 receptors. In 34-yr-old woman basal PRL levels of about 2000 ng/mL, 7.5 mg/day Bromocriptine (Br) for month neither reduced nor affected tumor size; this patient single photon emission tomography SPECT failed show any accumulation tracer. other patient, 27-yr-old man presenting cerebrospinal fluid rhinorrhea, were at 5000 ng/mL; magnetic resonance imaging (MRI) demonstrated huge tumor, and showed very intense concentration IBZM level adenoma. fell dramatically 530 ng/mL only 2.5 Br after 4 days; 6 days Br, 63 underwent surgery correct leakage. conclude that, these patients, pituitar...