Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis.
作者： Lei Liu , Jianfeng Dai , Yang O. Zhao , Sukanya Narasimhan , Ying Yang
关键词: Biology 、 Salivary gland 、 Janus kinase 、 Antimicrobial peptides 、 Virology 、 JAK-STAT signaling pathway 、 Anaplasma phagocytophilum 、 Ixodes scapularis 、 Tick 、 Human granulocytic anaplasmosis
摘要: Ixodes scapularis transmits the agent of human granulocytic anaplasmosis, among other pathogens. The mechanisms used by tick to control Anaplasma phagocytophilum are not known. We demonstrate that I. Janus kinase (JAK)–signaling transducer activator transcription (STAT) pathway plays a critical role in A. infection ticks. burden increases salivary glands and hemolymph when JAK-STAT is suppressed RNA interference. exerts its anti-Anaplasma activity presumably through STAT-regulated effectors. A gland gene family encoding 5.3-kDa antimicrobial peptides highly induced upon glands. Gene expression electrophoretic mobility shift assays showed peptide–encoding genes regulated STAT. Silencing these increased transmission mammalian host. These data suggest signaling key controlling ticks regulating peptides.
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