Intracranial pressure following penetrating ballistic-like brain injury in rats.
作者： Guo Wei , Xi-Chun M. Lu , Xiaofang Yang , Frank C. Tortella
关键词: Rat model 、 Brain trauma 、 Intracranial pressure 、 Cerebral perfusion pressure 、 Anesthesia 、 Physiological responses 、 Secondary phase 、 Medicine
摘要: Abstract Penetrating ballistic brain injury involves a leading shockwave producing temporary cavity causing substantial secondary injury. In response to the prevalence of this type trauma in military, rat model penetrating ballistic-like (PBBI) was established. This study focuses on cerebral physiological responses resulting from PBBI, specifically immediate and delayed changes intracranial pressure (ICP) perfusion (CPP). ICP/CPP measured continuously rats subjected probe insertion alone, or sham Immediately following transient (<0.1 sec) dramatic elevation ICP reaching 280.0 ± 86.0 mm Hg occurred, accompanied by profound decrease CPP −180.2 ± 90.1 mm Hg. emergent resolved spontaneously within seconds, but followed slowly-developing sustained phase, which peaked at 24 h post-injury, 37.2 ± 10.4 mm Hg, remained elevated until 72 h post-...
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