Rapid protection of the gastroduodenal mucosa against aspirin-induced damage by rabeprazole.

摘要: Summary Background  The ability of a proton pump inhibitor to reduce or prevent NSAID-induced gastroduodenal damage during the first 24 h has not been tested. Aim  To determine, whether oral rabeprazole, administered 5 h before initiation therapeutic dosing aspirin protects mucosa. Methods  Normal subjects were randomized into two groups – one received 20 mg at 07:00 hours and other placebo, 650 mg 12:00 hours, then q4 h for 3 days. Upper endoscopic examinations performed on all baseline, 24 72 h after aspirin. Gastroduodenal mucosal was scored. Results  Thirty compliant with study medications underwent three examinations. Salicylate concentrations similar placebo rabeprazole times. On Lanza scores significantly lower compared (1.3 ± 0.26 vs. 2.1 ± 0.26, P   0.05) (5.3 ± 1.8 8.0 ± 1.5; P > 0.05). Conclusions  Rabeprazole, initiated start aspirin, decreased antral erosion counts 24 h. These findings suggest that prophylaxis could concurrently administration.