Systemic treatment of vulvar cancer

摘要: Squamous cell carcinoma of the vulva is a rare disease, accounting for approximately 5% cancers female genital tract. Standard therapy early-stage vulvar cancer mainly comprises surgery and groins. In locally advanced or metastatic cancer, neoadjuvant definitive chemoradiation often considered as an alternative treatment option. Given its rarity, level evidence different modalities poor few clinical trials have been performed on this disease. Therefore indication criteria systemic in stage vary widely among countries institutions. This review focuses options patients with advanced, recurrent highlights need international multicenter approach to identify most effective therapeutic options.