Epidermal Growth Factor Receptor in Vulvar Malignancies and Its Relationship to Metastasis and Patient Survival

摘要: Abstract Objective. To evaluate the level of epidermal growth factor receptor (EGF-R) expression in vulvar malignancies and to determine if a correlation exists between EGF-R levels metastasis or patient survival. Methods. All patients with diagnosis invasive squamous cell carcinoma vulva who were treated at our institution primary radical vulvectomy inguinal lymph node dissection from 1983 1993 eligible for study. Sixty-one available tissue blocks benign epithelium, malignant lesion, groin (when positive) included Semiquantitative was determined blinded fashion utilizing immunohistochemical staining appropriate samples. Survival calculated Kaplan–Meier life table analysis based upon disease-free Results. A significant increase ( P Conclusions. There is progressive epithelium metastatic lesions within same patient. Increased malignancy significantly associated decreased histologically has association may predict