Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells.

摘要: A recent study reported on the efficacy of EGFR inhibitor locally advanced vulvar cancer. The aim this was to evaluate effect an tyrosine kinase (AG1478) alone and in combination with cisplatin cancer cells (A431 SW962). We detected overexpression A431 low expression SW962 cells. found that growth inhibitory AG1478 dependent upon level EGFR. combined treatment failed exert any synergistic or additive either cell line. In signaling pathway, decreased phosphorylation extracellular signal-regulated (ERK) protein B (Akt) parallel activity cells, while no changes ERK Akt were observed completely inhibited but not Cisplatin its increased p38 c-Jun N-terminal (JNK) both lines. summary, depending EGFR, by inhibiting activities Akt, ERK. Given absence effects from cisplatin, therapy should be considered cautiously.