Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma.

作者: Hao-yan Jiao , Wei-wei Su , Pei-bo Li , Yan Liao , Qian Zhou

DOI: 10.1016/J.PUPT.2015.07.002

关键词: AsthmaBronchoalveolar lavageCapsaicinAnesthesiaLungGuinea pigNaringinMedicineMethacholinePharmacologyOvalbumin

摘要: Naringin, a well known component isolated from Exocarpium Citri Grandis, has significant antitussive effects. Recently, Naringin exhibited novel anti-inflammatory effect in chronic inflammatory diseases. In this work, we firstly evaluated the effects of naringin on enhanced cough, airway hyper-responsiveness (AHR), and inflammation an ovalbumin-induced experimental cough-variant asthma (CVA) model guinea pigs. We investigated (18.4 mg/kg, per os, single dose or consecutively) cough to inhaled capsaicin after challenge with aerosolized antigen actively sensitized The AHR methacholine was 24 h determination. Airway assessed via bronchoalveolar lavage fluid (BALF) cytology lung histopathology. given consecutively, significantly reduced AHR, inhibited increases leukocytes, interleukin-4 (IL-4), IL-5, IL-13 BALF compared group. Moreover, pathologic changes tissues were clearly ameliorated by treatment. These results suggest that may be beneficial agent for CVA

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