Short courses of intravenous empirical antibiotic treatment in selected febrile neutropenic children with cancer.
作者： T. Lehrnbecher , A. Stanescu , J. Kühl
DOI: 10.1007/S15010-002-2094-1
关键词: Surgery 、 Discontinuation 、 Fever of unknown origin 、 Internal medicine 、 Absolute neutrophil count 、 Pediatric cancer 、 Neutropenia 、 Antibacterial agent 、 Leukopenia 、 Febrile neutropenia 、 Medicine
摘要: Background: Since the optimal duration of antibiotic therapy in febrile neutropenic patients is not clear, we evaluated safety and efficacy short courses intravenous treatment selected pediatric cancer admitted for fever neutropenia. Patients Methods: We retrospectively analyzed clinical course children with chemotherapy-induced neutropenia fever. All were treated empirical antibiotics. In episodes unknown origin (FUO), regimen allowed discontinuation antibiotics early hospital discharge regardless absolute neutrophil count (ANC) or evidence bone marrow recovery as long afebrile at least 24 h had been a minimum 72 h. Results: 106 occurred 56 patients. 84 classified FUO was discontinued ANC when met criteria described above. No death major complication occurred. None to be rehospitalized recurrent infection. Conclusion: Discontinuation seems safe effective are
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