Undifferentiated columnar cells on the gastric interfoveolar crest: A previously undescribed observation

作者: K. Mark Newbold , Fiona Macdonald , William H. Allum

DOI: 10.1002/PATH.1711550406

关键词: BiologyPathologyCellular differentiationIntestinal metaplasiaFoveolar cellGastritisAtrophic gastritisStomachGastric mucosaColumnar CellPathology and Forensic Medicine

摘要: We have observed and defined morphometrically histochemically an entity composed of groups undifferentiated columnar cells on the interfoveolar crest gastric mucosa. These are clearly distinct from either normal foveolar or regenerative epithelial associated with ulcer healing. They show a close association atrophic gastritis, particularly in presence type 3 sulphomucin-secreting intestinal metaplasia. termed this tip lesion since it is only tips mucosal folds. This has not been described previously. propose that these precursors metaplasia may also provide link between variant adeno-carcinoma.

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