Early Effect Markers and Exposure Determinants of Metalworking Fluids Among Metal Industry Workers: Protocol for a Field Study.

摘要: Exposure to aerosols from metalworking fluids (MWF) has previously been related a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures MWF and panel exposure effect biomarkers. We hypothesize that these are caused by particle generates oxidative stress, leading airway inflammation ultimately chronic diseases. aimed assess whether exposure, in particular as characterized its potential, is associated with biomarkers stress well genotoxic effects. The ultimate goal develop reduction strategies based determinants best predict MWF-related outcomes. The following relationships will be explored: (1) measured exposure; (2) preclinical clinical markers; (3) both exhaled breath condensate urine; (4) effect, effects symptoms. At least 90 workers France Switzerland (30 controls, 30 exposed straight aqueous MWF) were followed over three consecutive days after nonexposed period at two days. assessment MWF, metal, aldehyde, ultrafine number concentrations, the intrinsic potential aerosols. Furthermore, such metals, metabolites polycyclic aromatic hydrocarbons nitrosamine urine. Oxidative (malondialdehyde, 8-isoprostane, 8-hydroxy-2'-deoxyguanosine, nitrates, nitrites) nitric oxide, an marker, repeatedly Genotoxic assessed using buccal micronucleus cytome assay. statistical analyses include modelling function determinants, evolution symptoms long-term exposure. Data collection, which occurred January 2018 until June 2019, included 20 companies. At date writing, 100 subjects 29 nonoccupationally controls. This unique it comprises human biological samples, questionnaires, measurement. collected our all noninvasive useful monitoring workers. aim preventative outcomes. DERR1-10.2196/13744.