Biochemical Aspects of Teratology

摘要: Mammalian embryonic tissue shows a special degree of sensitivity to the action variety drugs as well environmental and nutritional factors when compared with response most tissues an adult organism. This may lead embryotoxic or teratogenic effects. Besides genetic defects acquired by parental germ cells biochemical peculiarities - in which at certain stages development deviate from organism represent prerequisite for action. In order get least some understanding mode effects, it is necessary study biochemistry mammalian different drugs. Up now very little known such tissue, quite contrast numerous studies that have been performed on amphibia birds. Studies organisms are great significance developmental biology. But since we know metabolism deviates considerably many respects other cells, data obtained birds only limited value perhaps prediction processes during normal pathological within species. Some years ago we, therefore, started survey several main metabolic pathways gain better proceeds these learn more about agents. In this paper aspects our recent presented difficulties limiting possible interference revealed. Three points will be discussed: 1. the choice methods used studies, 2. some examples and 3. the agents reactions tissue. We feel stress pertinent information can combination morphological used. Such include enzyme kinetics multi-enzyme systems whole embryos vitro vivo light microscopical, electron radioautographical culture studies. Therefore, joint project biochemical, pharmacological groups. From might differ quantitatively even qualitatively corresponding occuring nucleic acid features energy glucose discussed. The experiments cell fractions isolated incorporation radioactively labelled precursors. aerobic glycolysis pentose phosphate pathway. In third part substances – produce effects selected sets modified presented. antimetabolite 6–aminonicotinamidc (6–AN), alkylating agent cyclophosphamide (Endoxan) thalidomide. As far possible.the combined morphological, especially observations.