The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.
作者： P G Johnston , E R Fisher , H E Rockette , B Fisher , N Wolmark
DOI: 10.1200/JCO.1994.12.12.2640
关键词: Surgery 、 Thymidylate synthase 、 Gastroenterology 、 Rectum 、 Adjuvant 、 Stage (cooking) 、 Medicine 、 Internal medicine 、 Colorectal cancer 、 Chemotherapy 、 Immunohistochemistry 、 Cancer
摘要: PURPOSEWe assessed the prognostic importance of level thymidylate synthase (TS) expression in patients with primary rectal cancer and whether, for Dukes' B C patients, benefit chemotherapy was associated TS expression.PATIENTS AND METHODSThe cancers 294 801 enrolled on protocol R-01 National Surgical Adjuvant Breast Bowel Project (NSABP) immunohistochemically monoclonal antibody 106.RESULTSForty-nine percent whose tumors had low levels (n = 91) were disease free at 5 years compared 27% high 203; P < .01). Moreover, 60% alive after 40% (P The protein significantly stage .01); a more advanced higher TS. remai...
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