Advanced trends in controlling Helicobacter pylori infections using functional and therapeutically supplements in baby milk.

作者: Gamal M. Hamad , Tarek H. Taha , Nehal M. El-Deeb , Ali M. A. Alshehri

DOI: 10.1007/S13197-015-1875-3

关键词: Helicobacter pyloriMyrrhAntibioticsTerpenoidGastritisTraditional medicineAntimicrobialMedicineMicrobiologyHuman pathogenPhytochemical

摘要: Helicobacter pylori is a common human pathogen infecting about 30 % of children and 60 % adults worldwide. It responsible for diseases such as gastritis, peptic ulcer gastric cancer. H. treatment based on antibiotics with proton pump inhibitor, but therapy failure shown to be higher than 20 % essentially due an increasing in prevalence antibiotic-resistant bacteria, which has led the search alternative therapies. In this study, we discuss usage natural extracts mixture or complementary agents controlling infection so here, focused plant (Cloves, Pepper, Cumin, Sage, Pomegranate peel, Ginger, Myrrh Licorice). To that end, Phytochemical constituents detection like Tannins, Glycosides, Alkaloids, Flavonoids, Terpenoids, Saponins, Phenolic compounds, Reducing sugars, Volatile oils, Amino acids Proteins was demonstrated. Each extract examined individually combination its antimicrobial activity against pylori. Out used extracts, four mixes were prepared tested The antibacterial activities mixes, represented by diameter inhibition clear zone, recorded 21, 39, 23 28 mm. most potent mix (mix2) chosen mixed baby milk new infections babies.

参考文章(31)
R. Klimmek, C. Krettek, L. Szinicz, P. Eyer, N. Weger, Effects and biotransformation of 4-dimethylaminophenol in man and dog. Archives of Toxicology. ,vol. 53, pp. 275- 288 ,(1983) , 10.1007/BF00294993
Lutfun Nahar, Satyajit D. Sarker, Yashodharan Kumarasamy, Maureen Byres, Philip J. Cox, Marcel Jaspars, Screening seeds of some Scottish plants for free radical scavenging activity Phytotherapy Research. ,vol. 21, pp. 615- 621 ,(2007) , 10.1002/PTR.2129
Nahla A. Melake, Ghada H. Shaker, Magdy A. Salama, Incidence of Helicobacter pylori infection and their clarithromycin-resistant strains in otitis media with effusion regarding phenotypic and genotypic studies Journal of The Saudi Pharmaceutical Society. ,vol. 20, pp. 345- 353 ,(2012) , 10.1016/J.JSPS.2012.02.004
Costantino De Giacomo, Valeria Valdambrini, Francesca Lizzoli, Anna Gissi, Marina Palestra, Carmine Tinelli, Maurizio Zagari, Franco Bazzoli, A population-based survey on gastrointestinal tract symptoms and Helicobacter pylori infection in children and adolescents. Helicobacter. ,vol. 7, pp. 356- 363 ,(2002) , 10.1046/J.1523-5378.2002.00109.X
C. Shanthamma, K. S. Nagesh, Antibacterial activity of Curculigo orchioides rhizome extract on pathogenic bacteria African Journal of Microbiology Research. ,vol. 3, pp. 5- 9 ,(2009) , 10.5897/AJMR.9000048
D. Scott Merrell, Maria L. Goodrich, Glen Otto, Lucy S. Tompkins, Stanley Falkow, pH-Regulated Gene Expression of the Gastric Pathogen Helicobacter pylori Infection and Immunity. ,vol. 71, pp. 3529- 3539 ,(2003) , 10.1128/IAI.71.6.3529-3539.2003
Tamara Sabbi, Paola De Angelis, Luigi Dall'Oglio, Helicobacter pylori infection in children: management and pharmacotherapy Expert Opinion on Pharmacotherapy. ,vol. 9, pp. 577- 585 ,(2008) , 10.1517/14656566.9.4.577
Sharon Perry, Maria de la Luz Sanchez, Shufang Yang, Thomas Haggerty, Philip Hurst, Guillermo Perez-Perez, Julie Parsonnet, Gastroenteritis and transmission of Helicobacter pylori infection in households. Emerging Infectious Diseases. ,vol. 12, pp. 1701- 1708 ,(2006) , 10.3201/EID1211.060086