Pharmacokinetics of 2-butanol and its metabolites in the rat
作者： F. K. Dietz , M. Rodriguez-Giaxola , G. J. Traiger , V. J. Stella , K. J. Himmelstein
DOI: 10.1007/BF01061026
关键词: Volume of distribution 、 Body water 、 In vivo 、 Metabolism 、 Biotransformation 、 Chemistry 、 Pharmacology 、 Oral administration 、 Pharmacokinetics 、 Partition coefficient
摘要: A pharmacokinetic model is presented to describe the biotransformation of 2-butanol (2-OL) and its metabolites (2-butanone, 3-hydroxy-2-butanone, 2,3-butanediol) using in vivo experimental blood concentrations. flow limited developed simulate 2-OL, 2-butanone (2-ONE), 3-hydroxy-2-butanone (3H-2B), 2,3-butanediol (2,3-BD) concentrations rats after oral administration 2-OL. Assuming only important site 2-OL liver, tissues included are liver a volume distribution, essentially body water case metabolites. distribution coefficient found be necessary low concentration 3H-2B The need for this may due partitioning, binding, or altered transport rates from liver. Inhibition 2-ONE metabolism by has been explain time delay appearance Subsequent verification confirms mixed function oxidase inhibitory properties able elimination all four compounds Additionally, also simulates results obtained i.v. 2,3-BD.
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