Dose-dependent kinetics of inhaled methylethylketone in man
作者： Juha Liira , Gunnar Johanson , Vesa Riihimaki
DOI: 10.1016/0378-4274(90)90011-A
关键词:
摘要: Abstract Physiologically based stimulation of earlier human inhalation exposure to methylethylketone (MEK) at a concentration 200 ppm for 4 h suggested that the kinetics were dose-dependent. Two male volunteers therefore exposed MEK 3 concentrations: 25, and 400 ppm. Blood concentrations monitored during after exposure. The results showed clearly dose-dependent higher concentrations. Simulated 8 suggests saturation are reached an 50–100 ppm, depending on physical work load.
sci-hub.se 参考文章(12)
Winfried Kessler, Barbara Denk, Johannes G. Filser, Species-Specific Inhalation Pharmacokinetics of 2-Nitropropane, Methyl Ethyl Ketone, and n-Hexane Biologically Based Methods for Cancer Risk Assessment. pp. 123- 139 ,(1989) , 10.1007/978-1-4684-5625-7_10
L. Perbellini, F. Brugnone, P. Mozzo, V. Cocheo, D. Caretta, Methyl ethyl ketone exposure in industrial workers. Uptake and kinetics International Archives of Occupational and Environmental Health. ,vol. 54, pp. 73- 81 ,(1984) , 10.1007/BF00378730
G.D. DiVincenzo, C.J. Kaplan, J. Dedinas, Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance Toxicology and Applied Pharmacology. ,vol. 36, pp. 511- 522 ,(1976) , 10.1016/0041-008X(76)90230-1
Vera Fiserova-Bergerova, Maria L. Diaz, Determination and prediction of tissue-gas partition coefficients. International Archives of Occupational and Environmental Health. ,vol. 58, pp. 75- 87 ,(1986) , 10.1007/BF00378543
Y Takeuchi, Y Ono, N Hisanaga, M Iwata, M Aoyama, J Kitoh, Y Sugiura, An experimental study of the combined effects of n-hexane and methyl ethyl ketone. Occupational and Environmental Medicine. ,vol. 40, pp. 199- 203 ,(1983) , 10.1136/OEM.40.2.199
Esther M. Brown, William R. Hewitt, Dose-response relationships in ketone-induced potentiation of chloroform hepato- and nephrotoxicity Toxicology and Applied Pharmacology. ,vol. 76, pp. 437- 453 ,(1984) , 10.1016/0041-008X(84)90348-X
H. Altenkirch, G. Stoltenburg, H. M. Wagner, Experimental studies on hydrocarbon neuropathies induced by methyl-ethyl-ketone (MEK). Journal of Neurology. ,vol. 219, pp. 159- 170 ,(1978) , 10.1007/BF00314531
Michiko Miyasaka, Miho Kumai, Akio Koizumi, Takao Watanabe, Kazuyuki Kurasako, Kunihiko Sato, Masayuki Ikeda, Biological monitoring of occupational exposure to methyl ethyl ketone by means of urinalysis for methyl ethyl ketone itself International Archives of Occupational and Environmental Health. ,vol. 50, pp. 131- 137 ,(1982) , 10.1007/BF00378075
Gunnar Johanson, Per H. Näslund, Spreadsheet programming--a new approach in physiologically based modeling of solvent toxicokinetics. Toxicology Letters. ,vol. 41, pp. 115- 127 ,(1988) , 10.1016/0378-4274(88)90085-9
F. K. Dietz, M. Rodriguez-Giaxola, G. J. Traiger, V. J. Stella, K. J. Himmelstein, Pharmacokinetics of 2-butanol and its metabolites in the rat Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 9, pp. 553- 576 ,(1981) , 10.1007/BF01061026