Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

作者: F. Wang , C. B. Marshall , K. Yamamoto , G.-Y. Li , G. M. C. Gasmi-Seabrook

DOI: 10.1073/PNAS.1119073109

关键词: ChromatinP300-CBP Transcription FactorsCoactivatorTransactivationForkhead Transcription FactorsTranscription (biology)GeneticsTranscription factorBinding siteBiology

摘要: … CR2C-CR3 in the 2b3l conformation with CR2C bound to the c-Myb site and CR3 bound to the MLL site (A) and 2l3b with CR2C … The backbones of KIX, CR2C, CR3, and the linker are …

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