作者: John Snawder , Janice Chambers
DOI: 10.1080/03601238909372644
关键词: Paraoxon 、 Endocrinology 、 Internal medicine 、 Biology 、 Xenopus 、 Malaoxon 、 Parathion 、 Monocrotophos 、 Teratology 、 Malathion 、 African clawed frog 、 Toxicology
摘要: Four organophosphorus insecticides and the active metabolites of two phosphorothionate were tested for their toxic teratogenic effects on embryos Xenopus laevis. All compounds caused dose-dependent developmental defects, such as abnormal pigmentation, gut development, notochordal defects reduced growth. Malathion, malaoxon, parathion, paraoxon produced severe while monocrotophos dicrotophos considerably milder defects. NAD+ levels to a similar extent, regardless severity induced. Thus some commonly used are embryos, but level does not appear be important in causing